The Great Sword Destroying Wound Combo in Monster Hunter: The Wilderness is the True Charge Slash after destroying a wound, which can cause high damage. After using "Concentration Slash: Penetration" to destroy a wound, you can charge immediately and use "True Charge Slash".
What combo is good for Monster Hunter's Wilderness Great Sword to destroy wounds
After using "Concentration Knife: Penetration", you can charge immediately and use "True Charge Knife". Because destroying wounds, especially those on monster legs, has a tendency to knock down monsters, which makes them the main target of fully charged TCS.