The Holy Talisman in "Dragon Quest 3: HD-2D Remastered" is a very special item in the game. If you want the Holy Talisman, you can get it by saving Rubis, who is trapped. In a place that calls itself "Rupis' Tower". This journey is much tougher than the Spirit Temple, so be prepared.
How to get the Holy Amulet in Dragon Quest 3 Remake
The Holy Talisman is the final component of the Rainbow Drop and the hardest to obtain. It is obtained by rescuing Rubis, who is trapped in a place that calls itself "Rubys' Tower". This journey is much tougher than the Spirit Temple, so be prepared.
In the Tower of Rubis, you need to climb multiple floors, take detours, look for hidden floors, and fight familiar enemies again until you find Rubis' petrified body. Now, you need to use the Elf Flute to wake her up. Go to the town of Cole, located in the northeastern part of the map, and find it next to the hot springs in the north of the town.
Bring the Elf Flute and defeat the guarding boss, and you will be able to rescue Rubis. She will thank you for your help and give you the Holy Amulet as a thank you gift, the final piece of the puzzle to defeat Zoma. She also tells you your next destination - the temple. Head there now.